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PRF （Platelet-RichFibrin，富血小板纤维蛋白） 它是 2000年报道的第二代富血小板血液制品，它的制备方法是通过全血不添加任何抗凝剂立刻一次离心而获得的高浓度血小板纤维蛋白凝胶。 It contains a high concentration of platelets, leukocytes, monocytes, and various growth factors suspended in a fibrin matrix. 结果表明，使用 I-PRF 不仅能促进伤口顺利愈合和实现充分的骨整合，还能显著改善舒适度参数和术后恢复情况。 研究观察到，I-PRF 的应用加速了愈合过程，减轻了疼痛和水肿，促进了软硬组织的再生。

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2.IPRF临床形态为液态，是通过改变提取流程，提取的可注射型PRF，其内含有多种生长因子，如血小板，转化生长因子，血管内皮生长因子以及胰岛素样生长因子等，有研究表明其具有促进新生骨的功能当其与人工骨粉混合… 本系统评价旨在评估所有医学领域关于富血小板血浆 （PRP） 与注射用富血小板纤维蛋白 （i-PRF） 的比较有效性的所有可用证据。 在 PubMed、Scopus 和 Web of Science 中进行了截至 2024 年 9 月 30 日的全面检索。 PRF即富血小板纤维蛋白，是platelet-rich fibrin的简写。 在2001年由法国科学家Choukroun等人发现，是继富血小板血浆后第二代血小板浓缩制品，被定义为一个自体的白细胞和富血小板纤维生物材料。

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